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Mike Aug 13
Replying to @metoffice
Wrong already drizzle all morning

Verbal autopsy only

Cause of death on death certificate

Causes

Vasc

Resp

Neop

Infect

Unsp

Other Sp

Total

1. Vascular disease (Vasc)

4670

183

18

11

2593

94

7569

2. Respiratory diseases including pulmonary TB (Resp)

290

1438

13

16

971

46

2774

3. Neoplasm (Neop)

297

74

1182

24

670

41

2288

4. Infection (except Resp) (Infect)

103

38

2

217

399

49

808

5. Unspecified medical (unsp)

88

25

20

3

1596

15

1747

6.Other specific medical illness(Other Sp.)

372

53

12

194

1114

856

2601

Total

5820

1811

1247

465

7343

1101

17787

Finding autopsyAge limitPossible mutated genesClass of recommendation for referral of first-degree family members for clinical/genetic counselingLevel of evidence [References]
Unknown/Uncertain cause of SCD≤ 40Mainly ion channels genesIC [58] [59, 63, 64]
Hypertrophic cardiomyopathyNo limitSarcomeric and other disease related genesIC [59, 65]
Arrhythmogenic cardiomyopathyNo limitDesmosomal and other disease-related genesIC [66]
Dilated cardiomyopathyNo limitSarcomeric, cytoskeleton and other disease-related genesIC [59]
Premature atherosclerosisMen < 40 Women< 50Familial hypercholesterolemia genesIIaC [67, 68]
Thoracic aortic aneurysm / dissection / rupture with medial degenerationUnknownSyndromic and non-syndromic aortic aneurysm-related genesIC [6971]
Spontaneous coronary artery dissectionNo limitConnective tissue disease-related genesIIaC [72]
Pulmonary embolismUnknownHereditary thrombophilia genesIIba C [73]
SUDEPUnknownOverlap with ion channel-related genesIIaC [74, 75]
1
Finding autopsyAge limitPossible mutated genesClass of recommendation for referral of first-degree family members for clinical/genetic counselingLevel of evidence [References]
Unknown/Uncertain cause of SCD≤ 40Mainly ion channels genesIC [58] [59, 63, 64]
Hypertrophic cardiomyopathyNo limitSarcomeric and other disease related genesIC [59, 65]
Arrhythmogenic cardiomyopathyNo limitDesmosomal and other disease-related genesIC [66]
Dilated cardiomyopathyNo limitSarcomeric, cytoskeleton and other disease-related genesIC [59]
Premature atherosclerosisMen < 40 Women< 50Familial hypercholesterolemia genesIIaC [67, 68]
Thoracic aortic aneurysm / dissection / rupture with medial degenerationUnknownSyndromic and non-syndromic aortic aneurysm-related genesIC [6971]
Spontaneous coronary artery dissectionNo limitConnective tissue disease-related genesIIaC [72]
Pulmonary embolismUnknownHereditary thrombophilia genesIIba C [73]
SUDEPUnknownOverlap with ion channel-related genesIIaC [74, 75]
3

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