no data foundno data foundno data found
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Adverse Event FLOVENT HFA88 mcg Twice Daily
(n=203)%
FLOVENT HFA 220 mcg Twice Daily
(n = 204)%
FLOVENT HFA 440 mcg Twice Daily
(n = 202)%
Placebo
(n = 203)%
Ear, nose, and throat
  Upper respiratory tract infection 18 16 16 14
  Throat irritation 8 8 10 5
  Upper respiratory inflammation 2 5 5 1
  Sinusitis/sinus infection 6 7 4 3
  Hoarseness/dysphonia 2 3 6 < 1
Gastrointestinal
  Candidiasis mouth/throat and non-site specific 4 2 5 < 1
Lower respiratory
  Cough 4 6 4 5
  Bronchitis 2 2 6 5
Neurological
  Headache 11 7 5 6
В Modality (device)В ParameterВ AdvantagesВ DisadvantagesВ 
Regional stiffnessВ DopplerВ cfPWVaВ 
  • Inexpensive, portable

  • Can assess other cardiac and arterial features, e.g. LV hypertrophy, strain

  • Does not require a specific device

  • Faster than applanation tonometry

  • Identification of anatomical landmarks aids repeatability of measurement position

  • Can detect occlusive/atherosclerotic lesions that may affect PWV

В 
  • Operator-dependent skill

  • Sites of measurement limited by acoustic window

  • Lacks versatility for anatomical variations

  • Method of distance measurement overestimates distance

  • Calculation of cfPWV includes iliac and femoral arteries and excludes ascending aorta

In addition:
  • Transit time is determined through visual assessment using digital calipers, limited by temporal resolution

В 
Mechano- transducer (Complior)В cfPWVВ 
  • Similar to Doppler

In addition:
  • Automated device

  • Simultaneous measurements

В 
  • Similar to Doppler

In addition:
  • Variations in transit time algorithms used

  • Underestimates PWV compared with applanation tonometry

  • Cannot provide local wall assessment, where aortic condition may vary

В 
Applanation tonometry (SpyghmoCor)В cfPWVВ 
  • Inexpensive, portable

В 
  • Similar to Doppler

In addition:
  • Two consecutive recordings needed, heart rate variability may cause confounding

  • Local wall assessment not possible

В 
Local stiffnessВ CMRВ aPWV and ADВ 
  • Local and regional assessment of aorta possible

  • Relatively operator independent

  • Full visualization of the entire vessel

  • Imaging planes can be precisely placed with good repeatability

  • Greater spatial and temporal resolution (especially 3Tesla CMR) to study the temporal shift over smaller distances

  • Measurement not affected by anatomical variations, peripheral vascular disease or problems with using probes to detect waveforms

  • Other aspects of cardiac and arterial function can be assessed, e.g. strain and deformation

В 
  • Focal measurement may be prone to sampling error

  • Image analysis can be time-consuming and user dependent

  • Expensive

  • Longer examination time than other methods

  • Not possible with patients with metal implants, or with claustrophobia

  • PP is usually determined non-invasively and peripherally as it is more feasible than invasive measurement

В 

Database

Reason for exclusion

Number of entries excluded

Witham

Name unrecognised

1

Munich RE

Name ambiguous

2

Name unknown

7

Name unrecognised

6

Doubled record

6

EM-DAT

Name unknown

2

Name unrecognised

1

Doubled record

6

Trebled record

2 (1 event, 2 superfluous records removed)

В 

(13)Nova: “The Hunting the Quark.” (R) (11)Star Trek (13)Ragtime (R) (21)Shades of Black (25)Woman (31)Wall Street Week (4I)La Factoria De ‘La Risa (50) Express Yourself (67)The Fisherman

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(2)(4)News (7)The Reasoner Report (9)Movie: “Horror House” (1970). Frankie Avalon. Jill Haworth. Rock bottom (21)Erica‐Theonie (25)At the Top: Buddy Greco (31)Washington Week In Review (50)Jerseyfile (67)The Wilburn Brothers

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(2)News (4)To Tell the Truth (7)People, Places and Things (11)The F.B.I. (13)Dateline New Jersey (21)Washington Week in Review(31)On the Job (47)Movie: “Lin Demonic) Con Angel” (1962). Juan ose (5)Nova (67)Porter Wagoner

7:30

(2)The New Candid Camera (4)The Price Is Right (7)Strange Places (13)Agronsky and Company: News analysis (21)Wall Street Week (25)Memories of Prince Albert Hunt (31) Washington Straight Talk (67)Championship Wrestling

5:00

(2)All in the Family (R) (4)Emergency: Joe Kapp, Dena Dietrich, guests (R) (5)MOVIE: “The Jazz Singer” (1927). Al Jolson, May McAvoy. The earlytalkie classic, most notablenow for acoustics (7)Kung Fu: Anthony Zerbe, guest (R) (9)MOVIE: “Fort Apache” (1948). John Wayne, Henry Fonda. Soit's good, for the hundredth time (11)Hee Flaw: Chet Atkins, Jan Howard, guests(R) (413)Theater in America “Who's Happy Now?” (R) (21)Bill Moyers’ Intl. Report (31)At Large (41)Teatro De La Familia (50)Evening at Symphony

8:30

(2)The Jeffersons (R) (31)Consumer Survival Kit (07) Movie: “The Mole Men vs. Son of Hercules” (1963). Mark Forrest

9:00

(2)Mary Tyler Moore Show (R)(4)Movie: “The Bridge at Ramagen” (7) MOVIE: “Nicholas and Alexandra” (1971). (Part 1). Michael Jayston, Janet Suntan. Large, certainly, looming as the Kremlin and lust about A Sheavy (Television Premiere.) (11)News (21)World Press (31)Firing line (47)Misora Jihari on Stage (41)Amaras a Tu Projimo (50)Bill Moyers’ Intl Report

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